Fiber spinning technology

Fiber spinning technology

In 1995, MEDICA S.p.A developed its first Polysulfone (PS) hollow-fibre membrane, becoming the only Italian manufacturer of technological membranes for blood and water purification.

Fibre is one of the company's main growth areas: a dedicated clean room with an extrusion line for research and development activities has been installed at the Medolla headquarters along with three production lines at the SarMed plant.

The MediSulfone® membrane is characterised by its excellent performance in the purification of blood and aqueous solutions from contaminants, blood toxins, bacteria, viruses and endotoxins.

Its superior filtration capacity is due to the structure of the membrane, which has an inner wall characterised by a high density of small pores that define the two different available cut-off molecular weights of 15 kDa or 50 kDa.

The Versatile-PES® membrane was developed to meet the growing demand for broad-spectrum filter membranes for blood, plasma and water solutions. Thanks to its structure (polyethersulfone and polyvinylpyrrolidone polymer mix), which ensures an average pore size in the microfiltration range (approximately 0.2 μm) and good mechanical strength, Versatile-PES® is mainly used in plasma filtration and water microfiltration. More recently, additional versions of the Versatile PES® membrane with differential cut-offs (from 150 kDa to 800 kDa) have been developed for plasma fractionation applications.

Below is a summary of the main membranes developed by Medica with their main characteristics and applications:

Membranes MWCO (KDa) Fibre dimensions (µm):
Ø int./ wall thickness
M-PES low flux 10÷15 210/40 and 900/100 Low Flux Dialysis
M-PES high flux 40÷50 210/40 High Flux Dialysis
Medisulfone® ULTRA 15÷20 250/50 Water ultrafiltration
Medisulfone® EMO 40÷50 250/50 Hemofiltration Concentrator
Humidification fiber n.a. 250/50 and 250/65 Vapor transfer cartridge
Versatile-PES® Small 120÷180 210/40 Apheresis
Versatile-PES® Medium 350÷450 210/40 Apheresis
Versatile-PES® Large 750÷850 210/40 Apheresis
Versatile-PES® 0.15 µm 1.000÷1.200 300/85 and 900/150 Micro/plasma filtration
Versatile-PES® 0.45 µm 1.400÷1.600 300/85 Microfiltration

Medisulfone® and Versatile-PES® are registered trademarks of Medica S.p.A.